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Sept 21: In a setback for Intarcia Therapeutics, the FDAs Endocrinologic and Metabolic Drugs Advisory Committee voted unanimously that the benefits of its drug-device combination for Type 2 diabetes, ITCA 650, did not outweigh the risks

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Excessive lipid accumulation in hepatocytes, largely driven by upregulated de novo lipogenesis, impaired -oxidation, and diminished lipid export, initiates hepatic steatosis