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Therefore, early-life gut microbiota-host interactions critically shape immunological trajectories by integrating microbial colonization, innate receptor signaling, and tolerance programming, forming an essential developmental axis for pulmonary and systemic immune homeostasis

Drug Chem Toxicol

N., Pappin, D

Supporting the genetic basis of these associations, a recent hospital-based case-control study in Korean women identified variants in the melatonin receptor gene MTNR1A that were linked to BC risk, with certain polymorphisms interacting with NSW to further elevate susceptibility, highlighting a gene-environment interplay in circadian disruption-mediated breast carcinogenesis 195