fsp1 is a glutathione-independent ferroptosis suppressor

fsp1 is a glutathione-independent ferroptosis suppressor Multiple pathways regulating involved in ferroptosis Molecular mechanisms of FSP1-regulated ferroptosis

Name: fsp1 is a glutathione-independent ferroptosis suppressor Multiple pathways regulating involved in ferroptosis Molecular mechanisms of FSP1-regulated ferroptosis
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doi: 10.1126/science.1175202 217 HamiltonJACookADTakPP

As we age, collagen production slows down

The cultured SGN explants from WT or gpx1 / mice were treated with peroxynitrite and 2 mM NAC for 48 h (Figures 6A, 7A)

Together, these studies redefine GSH as a multifaceted regulator of cellular metabolism and compartment-specific homeostasis, rather than merely a passive antioxidant reservoir