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In agreement with previous proteome studies, SARS-CoV-2 reprograms major host pathways, including signaling pathways, transcription, splicing, translation, protein modification and folding, lipid, glycan, and nucleotide metabolism (Table 1, Supplementary Table 3, and Figures 5A, 7A,B) ( In addition, our proteome data highlight the importance of the IFN pathway and ISG effectors to prevent virus replication by interacting with various stages of the viral life cycle

doi: 10.1093/cdn/nzy005 23 ChakradharS

Initial titration over 714 days allows researchers to identify dose-limiting side effects before committing to higher therapeutic doses