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Mouse treatment 7- to 10-week-old WT and Gpx4 +/IEC mice received daily ferric maltol (0.4 mg, Shield Therapeutics PLC) and/or arachidonic acid (10 mg, Sigma, 10931) via oral gavage over the course of 6 days with or without -tocopherol supplementation (0.4 mg/ml, Sigma) in drinking water ad libitum

the simultaneous presence of mitochondrial abnormalities in cardiac and neural tissues of comorbid patients, suggesting a potential shared cellular defect

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