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Generally, mild side effects are reported with creatine use, for example, gastrointestinal discomfort (e.g., bloating or diarrhea), water retention, tension headache, nausea and/or vomiting, and sleep difficulties [58,65,66]

Specifically, an initial reduction followed by a substantial increase in beta-endorphin levels was observed, a pattern that suggests DSIPs impact on the opioidergic system, potentially playing a role in stress alleviation or adaptation processes

Although some clinical trials have shown no significant benefit of selenium in preventing cancer, a large body of evidence suggests that selenium is an effective anticancer agent in some cases

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