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These experimental results demonstrate that Ru SA+AC nanozymes attenuate OA progression by reducing joint destruction and inflammation, suppressing catabolic factors (MMP-13 and IL-6), and enhancing anabolic Col2A1 expression, while demonstrating outstanding in vivo biosafety with no observable structural or biochemical abnormalities in vital organs

Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways

Their precision and adaptability make peptides essential tools in modern laboratory research

These results suggest that m6A methyltransferases promote the translation of various RNAs, enhancing the expression of specific proteins and activating different downstream pathways that promote inflammation, thereby exacerbating atherosclerosis