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The resulting fermentation-enriched metabolites act on multiple nodes of the gutimmune axis, synergistically suppressing pro-inflammatory factors (e.g., TNF-) and enhancing antioxidant enzyme activity (e.g., SOD), thereby more effectively mitigating colitis

Clinical studies, although limited in size, report improvements in irritability, hyperactivity, sleep quality, communication, and oxidative stress biomarkers following supplementation with vitamin C, CoQ10, folinic acid, and mitochondrial support formulations (Mousavinejad et al., 2018

Glutathione levels also decrease with age

Several drugs and dietary factors can deplete glutathione, including: Acetaminophen, NSAIDs, DL-buthionine-S, R-sulfoximine, menadione (vitamin K3), and sodium deoxycholate