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Description

An ideal linker should: Different types of linkers can significantly affect the pharmacokinetics (PK), biodistribution, therapeutic effects, and safety of ADCs

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doi: 10.1158/1541-7786.Mcr-19-0691 90 WangYZhaoGCondelloSHuangHCardenasHTannerEJet al

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The N-terminal periplasmic domains also interact with the components of the cytoplasmic membrane-embedded platform of the secretion machinery, to promote channel opening, cargo docking, and subsequent release 26,27

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Treatment with MB at doses of 25 mg/kg and 50 mg/kg demonstrated dose-dependent hepatoprotective effects

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