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A 12-week facial cream study in 71 women with mild to advanced photoaging showed increased skin density and thickness, reduced laxity, improved clarity, and reduced fine lines and wrinkle depth with strongly stimulated dermal keratinocyte proliferation

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New England Journal of Medicine , 384(11), 989-1002

Other factors which involve a lack of information and potentially contribute to heterogeneity include concomitant illnesses and medications, both of which may affect antioxidant status