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We thank the UNC Center for AIDS Research (supported by NIH funded programme P30AI050410), the UNC Neuroscience Microscopy Core and the UNC Flow Cytometry Core Facility (supported in part by P30 CA016086)

In a 1992 study in rats, the major finding was that intraperitoneal DSIP injection increased the concentration of substance P a neurotransmitter positively correlated with the regulation of anxiety and mood15 in the hypothalamus, suggesting to the researchers that the peptide sharply decreases the classical manifestations of stress.16 Earlier studies in humans, namely a series of five trials published in 1983, came to similar conclusions, with better relaxation and apparently improved tolerance against psychic stress reported by the subjects.17 Its possible that the improved stress and anxiety markers were consequent to DSIP-associated sleep enhancements.18 Substance use recovery A study from 1984 published in European Neurology describes DSIPs potential use as a treatment for alcohol and opiate use disorders

CL Answer I do moderate exercise for about an hour a few times a week

Research indicates that IGF-1 helps improve cardiac output, stroke volume, contractility, and ejection fraction