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Control rats (group 1) are fed with standard diet, while the intervention rats are fed with iodine-free diet for 12 weeks to induce hypothyroidism (groups 2-4) which is continued for four more weeks to allow screening of hypothyroid status and L-Thyroxine-treatment

212222, www.ncbi.nlm.nih.gov/pmc/articles/PMC9377173/, Weschawalit, Sinee, et al

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With respect to hepatic glucose homeostasis, the effects of insulin receptor activation are specific phosphorylation and dephosphorylation events that lead to an increase in the storage of glucose with a concomitant decrease in hepatic gluconeogenesis and release of glucose to the circulation