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One may suggest that Nrf2 activation is specific to the disulfide forms of thiamine, not inherent in thiamine itself, as only the thiamine disulfides undergo intracellular reduction

The required dose is 20 to 40 mg/kg (i.e., 12 g in two divided doses) and significant effects are reported within a period of 3 months.[] ADVERSE EFFECTS ASSOCIATED WITH ORAL PREPARATIONS Local side effects can be expected like soreness of the gums caused by sucking the lozenges

Flavin-containing monooxygenases (FMO) : FMO enzymes catalyze oxidative reactions similar to cytochrome P450 enzymes but are involved in the metabolism of specific substrates, including some drugs and dietary compounds

Help protect against free radicals