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these components are well documented to produce oxidative damage, proteolytic cleavage of extracellular and cellular proteins, and direct cytotoxicity in other tissue contexts [56]

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In addition, second-line treatments such as GnRH agonists effectively reduce pain but are compromised by significant menopausal side effects and challenges with long-term tolerability, which has prompted the development of novel oral GnRH antagonists like elagolix, linzagolix, and relugolix that offer dose-dependent estrogen suppression and rapid reversibility

discovered that the expression level of TLR4, MYD88 and caspase-3 in the hippocampus were decreased by baicalin