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Atkin [email protected] Specialty section : This article was submitted to Cellular Neuropathology, a section of the journal Frontiers in Cellular Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

212 As an electron donor, NADH produced in the TCA cycle plays a crucial role in ATP synthesis by OXPHOS, which generates most of the energy through the H + gradient in animal cells

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