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Research has demonstrated that GHK-Cu treatment increases production of collagen (particularly type I and type III collagen, the predominant structural collagens in skin and connective tissues), glycosaminoglycans (including hyaluronic acid, which provides hydration, volume, and biochemical signaling in skin), decorin (a small proteoglycan involved in collagen fibril organization and growth factor regulation), and other matrix molecules critical for tissue structure and function

Plant Physiol Biochem 43:107116

Understanding these distinctions helps patients and providers engage in informed conversations, rather than viewing the peptides as competing or interchangeable options

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