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Antioxidants and statins (3-hydroxy-3-methylglutary-coenzyme A reductase inhibitors) A three-year randomized controlled trial in 160 patients with coronary heart disease (CHD) and low high-density-lipoprotein (HDL) levels found that a combination of simvastatin (Zocor) and niacin increased the HDL2 subfraction level (considered the most cardioprotective), inhibited the progression of coronary artery stenosis (narrowing), and decreased the frequency of cardiovascular events, such as myocardial infarction and stroke (130)

We also reported increased GSH levels during proliferation of rat hepatocytes such as plating primary cultures of rat hepatocytes under low density, which stimulates hepatocytes to shift from G 0 to G 1 phase of the cell cycle (Lu and Ge., 1992), and after 2/3 partial hepatectomy (PH) (Huang et al., 1998)

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However, various root and leaf protoplast cells, seed-related tissues, and active growth zones demonstrated significantly higher GPX activity