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Vitamin E and C: antioxidant defense mechanism via the Nrf2 pathway and oxidative stress reduction in ovarian tissue The dietary antioxidant Vitamins E (-tocopherol) and C (ascorbic acid) exhibit powerful protective functions against cellular oxidative damage while simultaneously regulating inflammatory responses

2 A healthy follicle is embedded in a well-organized dermal niche, and remodeling that niche could, in principle, create a more hospitable environment for follicular function

The distinct response to aspirin of these two strains, described in past studies carried out in our laboratory 18,19,20 , was indeed again made immediately apparent in our transcriptome analysis, which showed that aspirin altered the gene expression profile of EG110 cells to a greater and significantly different extent than that of EG103 cells (Figs 13)

Supplementary Material Acknowledgments We thank Carla Bartels (Medical Microbiology Department, Radboudumc) for culturing Bb spirochetes