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[23] In more severe or prolonged cases of pernicious anemia, nerve cell damage may occur

Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

Just penetrate into the fat (we all have some) below your skin so that your body can absorb the vitamin B12 and you will begin to quickly feel its benefits over the next 24hrs