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PDGF is secreted by activated platelets, endothelial, epithelial, glial cells as well as inflammatory cells and it targets a broad spectrum of cell type including, fibroblasts, pericytes, smooth muscle cells, glial cells or mesangial cells [140]

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Blood levels rise across the first several weekly doses and settle near steady state after about four weeks. That is why the four-week hold matters: the full effect of a dose change is not visible in the first few days