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The G value of + 13.0 kcal/mol for p.Arg106Pro most probably underestimates the effect of the variant because the WT model has the residues 110-112 and 108-112 missing in chains A and B, respectively, and the residues around the variant, including Arg106, have high B-factors, i.e., the position of the side chain does not have high accuracy due, for example, to dynamics

Currently there are many studies on DNA methylation and histone modification (Figure 3)

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Moreover, the SU11274 significantly reduced the in vitro migratory capacity of myeloma cells and treatment by the SU11274 decreased primary tumor growth and the capacity for liver colony formation in SCID mice [68]