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Science 369 , eaaz5900 (2020)

3.2 Effects of oral microbiota on gut microbiota 3.2.1 Bacterial transfer: how oral bacteria migrate to and colonize the gut Humans ingest 11.5 liters of saliva into the gut daily through swallowing, a process that represents a significant pathway for oral bacteria to disrupt the balance of gut microbiota

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We found that wild-type (WT) ACTL6A and the DNBL, CC, and NBC ACTL6A mutants reversed the inhibition of cell proliferation and the reduced GCLC protein expression induced by knocking down ACTL6A expression, but the ACTL6A HR-deleted mutant did not show this restorative effect (Fig