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Weight loss, regardless of the method achieved, can significantly impact menstrual regularity through multiple physiological pathways

In humans, the CYP450 enzyme that predominately catalyses the formation of NAPQI is CYP2E1, although in vitro CYP3A4, CYP2D6 and CYP1A2 have also been implicated in the formation of the toxic metabolite [18,19,20]

In addition, advanced glycation end-products (AGEs) are irreversible products from glycosylation reaction