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The NeuroEndoMetabolic (NEM) Stress Response describes another aspect of your bodys attempt to deal with stress

Angina (severe chest pain) or Arrhythmia (irregular heartbeat), uncontrolled or Blood vessel problems (eg, aortic stenosis, idiopathic subaortic stenosis) or Heart attack (within the last 3 months) or Heart failure (within the last 6 months) or Hypertension (high blood pressure), uncontrolled or Hypotension (low blood pressure) or Retinal disorders (eye problem) or Retinitis pigmentosa (an inherited eye disorder) or Stroke (within the last 6 months)Should not be used in patients with these conditions

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Proper dosage, timing, and product quality are all critical factors