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Retatrutide administered once weekly subcutaneously for 12 weeks resulted in a dose-dependent placebo-adjusted weight loss of up to 8.96 kg in the highest dose group and a placebo-adjusted HbA1c reduction of up to 1.6% in a phase II trial in individuals with T2DM [125]

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Specific genetic mutations that cause abnormal protein accumulation cause neurodegenerative diseases like Alzheimers and Parkinsons both of which are common types of dementias that arise from certain parts of the brain decaying faster than others

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