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The specific mechanism may involve a compromised intestinal barrier allowing antigens from the gut microbiota to penetrate and contact IgG antibodies, forming immune complexes that circulate in the bloodstream, including to the choroid plexus of the CNS

Lipinska et al., 2025), EVs have been applied using heterogeneous experimental protocols, with doses generally ranging from low g/mL concentrations (310 g/mL) to higher fixed doses around 120200 g/mL, and exposure times spanning from short co-culture periods of a few hours (up to 14 h) to prolonged treatments covering complete in vitro maturation windows according to the specie (approximately 1838 h)