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A 2023 Cochrane review found that Cerebrolysin provided no clear benefit for preventing death in acute ischemic stroke, and noted a potentially higher rate of spontaneous adverse events in some trial subgroups

Granitzer S, Ellinger I, Khan R, Gelles K, Widhalm R, Hengstschlger M, Zeisler H, Desoy G, upov L, ekov M, Salzer H, Gundacker C (2020) In vitro function and in situ localization of multidrug resistance-associated protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta

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However, one major drawback of bisulfite treatment is DNA degradation, which limits its use for sequencing long DNA molecules