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Hasan Ali O, Diem S, and Markert E, et al (2016) Characterization of nivolumab-associated skin reactions in patients with metastatic non-small cell lung cancer Oncoimmunology 5 (11) e1231292 PMID: 27999741 PMCID: 5139632 13

10.1038/s41593-022-01065-x 21

147 Three dogs had clinical signs suggestive of liver disease, which resolved uneventfully when azathioprine was discontinued

This ultimately resulted in the transition of phosphatidylinositol 4,5-bisphosphate into phosphatidylinositol-3, 4, 5-triphosphate, which in turn activated phosphoinositide dependent protein kinase-1 and stimulated AKT