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Ethics declarations Ethics approval and consent to participate Ethical approval for the human subjects procedures of this trial was obtained from the Yale University Institutional Review Board Human Investigation Committee (HIC approval #2000032211)

Nicotine addiction causes this during withdrawal as the brain struggles without its usual dopamine stimulation, leading to mood instability

BLAINE Right you are, GENERAL! Advertising card by Straiton & Storms Cigars, New York for Capadura cigars 1884 ( Curators note: James Gillespie Blaine [1830-1893] was the Republican nominee for president in 1884 and lost to Grover Cleveland

To hell with tired, Ill sleep when Im dead