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Consistent with the in vitro findings, GHK-Cu increased antioxidant enzymes and decreased pro-inflammatory cytokines in vivo

Although Sorafenib is a kinase inhibitor with multiple targets including RTKs and RAF, its treatment did not affect the total tyrosyl phosphorylation and ERK phosphorylation in TamR cells (Figure S5), indicating that inhibition of TamR ER+ breast cancer cell growth by Sorafenib under the concentration used is not through inhibition of RTKs and RAF

No direct pharmacological interactions are known between GHK-Cu and Tirzepatide

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