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PLoS One 7 (6), e38565

High glucose and hypoxia-mediated damage to human brain microvessel endothelial cells induces an altered, pro-inflammatory phenotype in BV-2 microglia in vitro

Evidence-based levers that reliably move the needle: A sustainable calorie deficit with adequate protein Resistance training plus daily movement Sleep and stress management (often underestimated) Clinician-guided options when appropriate, including FDA-approved obesity medications (e.g., Wegovy and Zepbound ) and weight loss injections A good rule of thumb: don't outsource a fundamentals problem to an unproven tool

The incretin arms suppress appetite and improve glucose control