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Individuals with severe kidney failure, decompensated liver disease, congestive heart failure with fluid overload, non-ketonic hyper-glycemia, or known hypersensitivity to formulation components should not receive glycine.Patients on clozapine should likewise avoid glycine unless supervised closely, as it may blunt clozapines efficacy

In some embodiments, the otic formulation or composition comprises about 7% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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