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Based on these studies, commonly identified structures include the anterior cingulate cortex, hippocampus, prefrontal cortex, entorhinal cortex, amygdala, and striatum

Common medications include corticosteroids, methotrexate, antiTNF antibodies, and intravenous immunoglobulin

In certain embodiments, any controlled-release otic formulation described herein increases the exposure of an active agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 100%, or higher than 100%, compared to an otic formulation that is not a controlled-release otic formulation