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Key Takeaways GHK-Cu (copper tripeptide-1) is the most studied injectable peptide for collagen induction, with gene-expression profiling showing modulation of over 4,000 genes relevant to tissue remodeling (Pickart and Margolina, 2018, Open Access Maced J Med Sci)

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56 However, if the patient continues to present evidence of liver dysfunction beyond persistent ALT elevation (satisfying KCH criteria of acidosis, elevated creatinine, hyperbilirubiniemia, coagulopathy and encephalopathy), then NAC therapy should be continued as these indicators portend a poor prognosis regardless of transaminase levels