Stress that is experienced suddenly raises heart rate and blood pressure as well as gluconeogenesis, glycogenolysis, lipolysis, and hepatic glucose release
su respuesta descrita es no lineal (forma de U) respecto a dosis y tiempo (PMID 6145137), un patrn distinto al de agentes con relacin dosis-efecto ms directa
The timing of benefit and the timing of loss both matter
The primary aim of this study is to elucidate the molecular mechanisms underlying CP-induced ovarian injury, with a focus on oxidative stress, inflammatory signaling, and apoptotic pathways, focusing on nuclear factor-kappa B (NF-B), nuclear factor erythroid-2-related factor 2/heme oxygenase-1 (Nrf2/HO-1), Toll-like receptor 4 (TLR4), nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, silent information regulator-1 (SIRT1), and other signaling pathways involved in the pathogenesis of ovarian injury caused by CP