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Exposure to ultraviolet radiation is the most important factor that causes undesirable hyperpigmentation

Moreover, more recently a family of proteins called peroxiredoxins has been recognized as catalyzing the reduction of H 2 O 2 by GSH and/or other thiols, but with cysteine in its thiolate form, in their active sites rather than selenium-cysteine ( -dicarbonyls are also involved in ROS generation

The use of vitamin C (ascorbic acid) serums is a well-established and mainstream approach for treating melasma pigmentation

These keystone species are responsible for producing short-chain fatty acids (SCFAs) like butyrate, which help keep the gut lining healthy and suppress inflammation