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Regarding neuroplasticity regulation, suppressed Notch/DNER signaling and dysregulated Wnt/AXIN1 pathway may compromise hippocampal neurogenesis [26, 53, 54], while disrupted NTRK2-BDNF signaling and impaired Nr-CAM-mediated cell adhesion could lead to decreased synaptophysin synthesis and dendritic complexity [55]

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