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Sorafenib [a small-molecule multi-kinase inhibitor that targets vascular endothelial growth factor receptors (VEGFRs) rapidly accelerated fibrosarcoma (RAF) and other protein kinases] has been regarded as the standard of treatment for patients with advanced HCC since 2007 ( Tivantinib, a staurosporine derivative, is a non-ATP competitive selective small-molecule inhibitor and acts mainly as an anti c-Met inhibitor (Santoro et al., 2013)

BPC-157 promotes the activation of ERK1/2 in endothelial cells To evaluate the effect of BPC-157 on intracellular signal transduction, the phosphorylation levels of ERK1/2, JNK, and p38 mitogen-activated protein kinase (MAPK) were examined in HUVECs

The addition of an acetyl group (COCH) to the alpha-amino group of the N-terminal alanine creates a modified peptide with potentially altered stability and cellular interaction characteristics

Epithalon also appears to inhibit the activity of Caspase-3, a key enzyme that is considered to promote apoptosis (programmed cell death)