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Patisiran: first global approval

In turn, this causes an increase in thyroid volume

Thus, both CI and CII exhibited a significant lower activity, which was confirmed by a lower state apparent upon Gclc ablation (Supplementary Fig

Further analysis of signaling pathways confirmed that PD effectively upregulated endogenous TGF-/Nodal signaling and downstream Smad2/3 transduction, while concurrently downregulating BMP signaling, leading to robust DE formation