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Omatsu T, Naito Y, Handa O, et al

As it was previously demonstrated that lysine lactylation was induced by neural excitation, a key molecular mechanism for the development of epilepsy [96], with the detailed results showing the positive association of increase of lysine lactylation and the expression of the immediate-early gene marker of neuronal activity c-Fos [97], it is hypothesized that histone delactylation by HDAC1-3 may inhibit the development of epilepsy and prevent seizures

Assay of testosterone, estradiol, and progesterone Blood samples were collected from all groups for three weeks (the first, sixth, and twelfth) from the ear vein in heparinized tubes from each rabbit and placed immediately on ice

The cost-benefit analysis does not support it