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For example, 28 percent of the CABG patients in the Du-Toit study had undergone prior cardiac surgeries, while patients with prior CABG or PCI were excluded from the SYNTAX trial [134] and the SYNTAX trial included patients with de novo 3-vessel disease, left main (LM), or both, unlike the Du-Toit study

It also plays a role in maintaining the myelin sheath that protects nerve cells and ensures smooth nerve transmission

Specifically, lactate triggers mitochondrial fission 1 (Fis1) lactylation at lysine 20, which promotes excessive mitochondrial fission, leading to ATP depletion, mtROS overproduction, and mitochondrial apoptosis, exacerbating S-AKI