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Nevertheless, persistent SASP inhibition may interfere with normal intercellular communication, and therapeutic benefits remain transient owing to SASP reactivation after treatment discontinuation

In our study, we observed that Cx32 levels decreased within 1 h in APAP-treated wild-type mice, whereas in hepsin-/- mice, this reduction occurred at 2 h post-treatment (Fig

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The modification reduces overall positive charge at physiological pH, potentially affecting cellular interactions, membrane permeability, and receptor binding characteristics