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For example, it should be considered that, compared to other endogenous orexigens, ghrelin has only modest effects on food intake in animal models

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Lu Y, Li X, Geng D, Mei N, Wu PY, Huang CC, et al

Targeting CYP51A1: small-Molecule inhibitors and therapeutic potential The cholesterol biosynthetic pathway has proven to be a successful target in drug development, as exemplified by statins for hypercholesterolemia and azole antifungals for infectious diseases [97, 98]