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Science (2004) 304(5674):115860

Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore

High-dose acetylcysteine for high-risk (massive) acetaminophen overdose The rationale for using high-dose acetylcysteine: (1) Evidence shows that standard doses of acetylcysteine can be inadequate in the context of massive poisoning

For example, a study published in the European Journal of Nutrition found that oral supplementation with S-acetyl L-glutathione was effective in increasing body stores of glutathione, with significant increases observed in lymphocytes and buccal cells