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In vitro and in vivo studies have evaluated the biological functions of GHR in breast cancer by silencing GHR and showed that GHR reduction leads to the inhibition of cell proliferation, the cell-cycle arrest in G1-S phase transition, tumor growth, and cell apoptosis induction of breast cancer cell lines, speculating these effects might be due to the inhibition of the Raf/MEK/ERK signaling pathway (Zhu et al., 2020)
A previous study showed that APP expression is subject to DNA methylation regulation (hypomethylation of the APP gene) [138] and the demethylation of the APP gene with age may have a significant influence on the development of A deposition [139]
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