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Funding This work was supported by the National Natural Science Foundation of China (31970699), the Guangdong Basic and Applied Basic Research Foundation (2021A1515010766 and 2019A1515011030), the Guang-dong Provincial Key Laboratory of Construction Foundation(2019B030301005), the Key-Area Research and Development Program of Guangdong Province (2020B1111110003), and the National Major Special Projects for the Creation and Manufacture of New Drugs(2019ZX09301104)