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225,226,227,228 Backbone modification The modification strategies used in first-generation NADs have focused on modification of the phosphate backbone, mainly using other types of groups to replace the non-bridging oxygen atoms in the phosphate backbone, such as phosphorothioate (PS), methyl phosphate, and boranophosphate

Marom EM, Moran CA, Piu P, Correa AM, Kim ES, Komaki R, Erasmus JJ, Hofstetter WL, Rice DC, SGb S

J Urol 1997

This persistence and functional specialization of Mo-AMs underscores their central role in driving sustained inflammation, secreting profibrotic mediators like TGF-, IL-10, and CCL18, and orchestrating fibroblast activation and ECM deposition (103, 105)