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It is worth noting that the compounds were tested in vitro using the Caco2 cell line and did not induce cell damage or death, which suggests a favorable preliminary safety profile and supports their potential for future drug development [62]

However, the model adjusted for sex revealed a significant condition-by-sex interaction on Glx/tNAA change ( F 1,242 = 4.81, P = 0.029), with differences between placebo and naltrexone pretreatment conditions being more pronounced in males than in females (Fig

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