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TNF--induced DNaseII reduction might be responsible for the accumulation of dsDNA in FLSs, as TNF- stimulation decreased both the mRNA and protein levels of DNaseII ( 3.4 Other factors regulate cGAS-STING signaling in RA The cGAS-STING-NF-B signaling, which represents another arm of the STING signaling network, has been documented to induce macrophage pyroptosis, a process that holds significant importance in RA ( The role of the tumor suppressor gene p53 in RA pathogenesis has been explored in AIA rats ( R211* significantly alleviated arthritis symptoms and joint destruction in AIA rats, which were similar to those observed in MTX-treated rats

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Serum GSH measurement Samples were prepared and derivatized for HPLC analysis using procedures (with slight modifications) as described previously (24, 25)