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Tissue was obtained with regulated informed consent from all individuals by the UoB Ethical Tissue Bank (an ethically approved human research tissue bank, licensed by the Human Tissue Authority (HTA), Licence number: 12191) with approval from the National Research Ethics Service (NRES) Committee Yorkshire & The HumberLeeds East (approval number 17/YH/0086)

In individuals homozygous for the C677T polymorphism in the MTHFR gene, low riboflavin status is associated with elevated plasma homocysteine, and in turn linked with a higher risk of cardiovascular disease and other chronic diseases (13, 14)

Orders are despatched from the UK

doi: 10.1097/MPG.0000000000003643